三百四十八章 左氧系列化(1 / 1)

两天后,生产上就开始试车,溶解,冷却,离心都很顺利,固体湿料很快进真空烘箱了。

产品有结晶水,为一水合物,烘干条件需要严格控制,温度与真空度不匹配,水份指标就很难合格,小试量小不会出现这问题,只能通过生产直接调试。

五小时后,第一次中控取样检测水份,托盘外面产品水份为百分之一,表面已开始发白,中间为百分之十一,色泽带浅绿色的底,外观上就明显不一样。

这可怎么办?合格品要求是水份范围百分之三点五到五,内外表面不统一,无法通过中控得出准确的结论,公司又没多余的双锥真空烘箱,采购得几个月呢。

“左氧盐酸盐怎么用的?灌胶囊用的,我们烘得偏干些,在包装袋里上下反复倒几次混匀它即可,含量高些直接向客户说明,他们总会接受的。”吴总想了想决定:“再烘二小时后出料。”

二小时后,产品出料了,隔着塑料袋手工粉碎混匀后取样分析,其它指标都合格,水份烘到了百分之一点七了。

蒋总跟客户商量后,客户连连点头说:“没事,没事,只要把货给我就行了,这不是关键指标。”说完急忙把汇票递上,欢天喜地地去仓库提货了。

抗击非典的特殊时期,抢到货就是利润,又是口服的,水份低可以多加辅料降低成本,客户自然放宽了要求。而对企业呢,分子量增大,销售价相对提高,增加了几个百分点的利润。

非典是暂时的,过去后厂家肯定不接受不符合质量标准的左氧盐酸盐产品,我们还得按可控的方法进行烘干。

王近之想了想,向吴总提议道:“要不,近段时间可先把碘海醇粗品的双锥烘箱洗干净,用着左氧盐酸盐的烘干,碘海醇成品可以暂时地把粗品湿料用水溶解,分层除去正丁醇,再加水夹带,蒸去残留的正丁醇的方法控制溶剂残留。”

“就这么干吧,把工艺参数得到后再采购正规的双锥烘干设备。”吴总略一沉思,点头答应:“操作工还是由左氧车间出,碘海醇车间在24小时内把设备腾出来。”

左氧盐酸盐的成品是针状晶体,流动性很好,不会粘壁。在双锥中烘干的均一性相当好,第一次取样不同位置的六个点,水份指标全部为百分之八点三到八点四,波动范围很小,第二次取样时,六个点的水份最大的为百分之五点六,最小的为百分之四点九。第三次取样,六个点全部落在客户要求的百分之三点五至百分之五之间,第一批试车就顺利完成了设定的标准。

生意好的吓人,收钱收到手软,从领导到操作工,人人眉开眼笑。吴总又思考开了,对王近之与阮森明说:“我查了一下欧美药典,左氧商品化的还有甲磺酸盐与乳酸盐,要不,我们把这两种盐也给小试完成先备着,看一看市场反馈?”

做盐的技术相对简单,虽然没有实验员,两个人应当也能搞定,两人商量了一下,开始行动。

左氧甲碘酸盐一天就搞定了,经过检测,符合欧州药典的质量标准。乳酸盐却不太好搞,按盐酸盐一样的配比与结晶条件进行投料,冷冻后结出了乳白色的固体,但一过滤,全部透过了滤纸,结晶体有如乳化的牛奶,颗粒太细了。

“左氧氟沙星乳酸盐有三百千克的询单,是口服级的,甲磺酸盐暂时没销路。”联合会议上,蒋总向大伙反馈了近段时间出门市场调查的情况。

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