四百六十六章 参于国标制订(1 / 1)

想不到还有这水平,王近之与陈骨良十分开心,两人最大的弱点就是外文水平弱,现在,有人把这短板补上,查资料就方便了。

根据资料汇总,双环母核的路线报道不多,只有两条,一条是通过烯醇式的甲基化反应,引入β-甲基,然后水解,再与丙二酸单对硝基苄酯镁盐反应,延长碳链,形成羰基酯结构,再通过与叠氮盐发生重氮化反应,然后,在铑盐催化下经卡宾环合得到β-甲基碳青霉烯双环母核。优点是条件温和,容易制备,但是反应路线较长,收率不高,只有30%左右。

另一条路线报道是采用手性辅助剂在四氯化钛催化下反应,引入β-甲基,然后,通过水解,以及与丙二酸单酯对硝基苄酯反应,延长碳链,形成β-羰基酯结构,再与二乙酸碘苯反应得到一个碘叶立德,最后在对甲苯碘酸催化下与内酰胺环上的氮原子发生环合,再经二苯氧基磷酰氯活化,得到β-甲基碳青霉烯双环母核。将环己酮和邻羟基苯甲酰胺反应,然后与溴代丙酰溴反应得到目标产物双核母核。

技术资料是周一强查得的,自然有路线的优先选择权,他选择了报道收率比较高的路线二,熊伟安组承接了路线一,再次上报各种侧链与辅料。

新成立的碳青霉烯组辅料采购中,左氧组紧锣密鼓地在进行新车间开车前的准备工作。因为老车间主任阮森民是小学毕业,无文字组织能力,石一峰跟着李彪奇做了一个月的左氧,对这产品已经有所了解,编写车间资料的人手缺乏,石一峰又自告奋勇下车间。大学生愿意主动承担重任上一线的人不多,王近之自然乐观其成,所以,推荐了他到左氧车间担任工艺员。

公司同时提拨原班组长俞华树为车间副主任,阮森民、石一峰与俞华树三人成为车间领导班子,开始水试。石一峰干活有些拼,肯钻肯学肯吃苦,所以,很快引起公司领导的重视,自个力荐的嘛,王近之也感到脸上有光。

正在左氧车间,向石一峰交代水试的注意事项,林利勇手机通知参加一个紧急会议,说:“国家局在制订碘海醇国家标准的过程中遇到难题,向我们公司求援了,你现在立即上小会议室。”

王近之一路小跑进入会议室中,只见徐龙川、卫诚、赵定岳等已在现场,一个个都脸红红的透着些兴奋,受到国家局邀请,参于碘海醇国家标准的制订,对企业绝对是一种荣耀。

林利勇介绍说:“本次碘海醇国标制定,国家局委托北京药物研究所具体负责,他们在分析方法的研究与实施过程中,遇到了检测相关杂质A,即原料水解物,因与主峰较接近,用液相色谱有拖尾,所以,得用硅胶板进行点板对比。在爬板操作过程中,斑点总是出现偏差,具体什么问题手机里说不清,要求公司派人协助与解答。”

一听是检测方法问题,大家把眼光都聚集到了卫诚与赵定岳的身上,公司所有产品的分析方法都是他们俩指挥下开发的,出差北京与药检所,他们是责无旁贷的人选。讨论到最后,公司决定派他们进京与药检所联系,协助完成碘海醇国标的确立。

会议结束后,卫诚、赵定岳与王近之又小范围地作了协商,备齐了分析上可能出现的材料,如标准品,硅胶板等等,化学原料带上飞机,不是件闹着玩的事,万一作危险品被挡下,丑就出大了。

他们出差三天后,王近之手机联系了赵定岳,问道:“药物所的检测究竟是怎么一回事,问题解决进度如何?”

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