四百六十九章 双环母核(1 / 1)

三个猪头?两人十分惊讶地相互看了看,连续一周套着橡皮防毒面具,脸被闷得通红,不就象是三个红烧大猪头嘛。

三人喝酒也无趣,王近之同时邀请了赵定岳、陈骨良、朱炜及张亭婷几位酒量好的伙计加入,比酒量,张朋袅是最差的,比酒德却不输于人,豪爽地干杯,三瓶下去已是摇摇晃晃,大家劝着别喝,又硬着头皮自个抢着喝了一瓶。酒席结束,把大堆的酒瓶堆到自个身前,非要人家拿手机给照一张。

有图有真象,一张小脸,九个啤酒瓶,几天后,张九瓶的大号在公司叫响了,酒风好,胆子大,风头一下盖过了张亭婷。

加氢是王者的老本行,环合是分子内关环,都特顺利,得到四圆环混旋体。可是,这混旋体有两个手性中心,内外消旋体混和,用酒石酸拆分,一天一排六七个实验,三天就二十个,没半点效果。另换拆分剂又得重新采购,得耗费十多天的时间,并且由原理分析,最好的结果也就是拆出左右旋,内外旋的旋光度是一模一样的,用普通拆分完成它沒有可能。

对于拆分,王近之只搞过单个手性中心的,双手性中心的没什么接触,实在也想不出什么办法,正办公室里发呆着,方擒虎方总进来催作业了说:“你们又进了三个大学生,怎么叫你们做的车间条件试验还没完成?这关联到后面产品搬迁的设计呢。”

了解到王近之他们在用氰化钠合成4-AA后,方总勃然大怒说:“乱弹琴,这么种工艺,那怕利润百分之一千,我们公司也不允许你们进行实施,万一出事,全公司都得关门大吉,立即给我把实验停了。”

你又不是我的直接领导,论在誓太灵的资历晚我几年,贡献的话恐怕也差我几份,王近之的火气很快地窜了上来,当场双方就起了争执,吵得面红耳赤的。

吴总闻声过来劝架,考虑到公司已启动了与厦大的不对称加氢合成,暑假后就正式实验,商量的结果,停止了氰化钠路线。

停掉更好,不用整天担惊受怕地与死神打交道,虽然面子上有些挂不住,可内心深处,王近之还是赞同方总的意见的。先集中精力看一看以4-AA为出发原料合成双核母核的实验进展吧。王近之召集了周一强与熊伟安两个课题组他们汇报项目进展。

周一强组的合成止步于碘叶立及对甲苯碘酸催化下与内酰胺环上的氮原子发生环合上,反应转化率极低,只有百分之四十多一些,而专利报道为百分之九十六,天差地别又没找到原因。

周一强感到十分的憋气说:“专利资料总是真真假假,谁也说不清的,课题组已经尽力了,做了无数的优化。”

熊伟安组的小试却十分顺利,资料收率只有30%左右,他们却做到66%,整整超出报道值的一倍多,只是,在铑盐催化下经卡宾环合得到β-甲基碳青霉烯双环母核,铑催化剂用一次就失活了,这催化剂价格很高,对成本影响及大,攻破催化剂回收这一关,整条工艺就算完成了。因为是均相催化剂,一种复杂的络合物,难度比钯碳回收等难得多。

周一强平时为人极和善,人缘很好,熊伟安的性格却是又孤僻又小气,同事间津津乐道的事就是他贪小便宜,每天傍晚都借用别人的饭卡在公司食堂另打一份饭,送给他开服装店的老婆。

小试成功了,只是熊伟安的运气好而已,更何况,资料又不是他查的,而是周一强查好给他的。如当时选择的路线相反的话,结果也会截然不同。公司里很多人都这么认为。

那么,把熊伟安暂时安排到中试车间,配合叶日月进行最后的接管与水试吧,吴总作出决定。

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